(3S,6S)-3-(3H-imidazol-4-ylmethyl)-1,4-diazabicyclo[4.4.0]decane-2,5-dione
Cyclo(his-pro),Cyclo(histidyl-proline),Histidylproline diketopiperazine
CAS: 53109-32-3
Molecular Formula: C11H14N4O2
(3S,6S)-3-(3H-imidazol-4-ylmethyl)-1,4-diazabicyclo[4.4.0]decane-2,5-dione - Names and Identifiers
(3S,6S)-3-(3H-imidazol-4-ylmethyl)-1,4-diazabicyclo[4.4.0]decane-2,5-dione - Physico-chemical Properties
| Molecular Formula | C11H14N4O2 |
| Molar Mass | 234.25 |
| Density | 1.41±0.1 g/cm3(Predicted) |
| Melting Point | 162-164 °C |
| Boling Point | 659.3±48.0 °C(Predicted) |
| pKa | 12.73±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Use | Cyclo(His-Pro) is a cyclic dipeptide structurally related to proinflammatory releasing hormone. |
| In vitro study | cyclo(his-pro) (Cyclo(histidyl-proline); 50 μM; 1-48 hours) increases the nuclear level of Nrf2 and inhibits NF-κB nuclear translocation. Cyclo(His-Pro) alone has no effect on nuclear translocation of these transcription factors. cyclo(his-pro) (50 μM; prior to PQ exposure for 48 hours) abolishes protein nitration that followed paraquat (PQ) exposure and lessenes its functional consequences, as shown by decrease in cell apoptosis, detected by caspase 3 activity and by cytochrome c release. Cyclo(his-pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway. Western Blot Analysis Cell Line: PC12 cells Concentration: 50 μM Incubation Time: 1, 2, 4, 8, 24, 48 hours Result: Increased the nuclear level of Nrf2 and inhibited NF-κB nuclear translocation. |
| In vivo study | Cyclo(his-pro) (Cyclo(histidyl-proline); 1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear oedema confirming that it can exert anti-inflammatory effect. Cyclo(his-pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, Cyclo(his-pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress. Animal Model: Sixty two/three month-old male C57BL/6 mice (25-30 g) Dosage: 1.8 mg/ear Administration: Topical application on the right ear; 30 min prior to TPA Result: Reduced TPA-induced ear oedema. |
(3S,6S)-3-(3H-imidazol-4-ylmethyl)-1,4-diazabicyclo[4.4.0]decane-2,5-dione - Risk and Safety
| WGK Germany | 3 |
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Spot supply
Product Name: Protirelin Impurity 5 (Protirelin EP Impurity E) Visit Supplier Webpage Request for quotationCAS: 53109-32-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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